Evidence-based patient choice: inevitable or impossible?

Informed shared decision making in multiple sclerosis--inevitable or impossible?

Patients and health authorities increasingly claim active roles in health care decision making processes. As immune therapies in MS are partially effective MS is a prototypic condition for a shared decision making process. The treatment of acute relapses and the initiation, change or withdrawal of so called disease-modifying treatments are key decisions in MS management. We developed two decisi...

Medical Malpractice: A Preventable or Inevitable Issue

Evidence that BRCA1- or BRCA2-associated cancers are not inevitable.

Inheriting a BRCA1 or BRCA2 gene mutation can cause a deficiency in repairing complex DNA damage. This step leads to genomic instability and probably contributes to an inherited predisposition to breast and ovarian cancer. Complex DNA damage has been viewed as an integral part of DNA replication before cell division. It causes temporary replication blocks, replication fork collapse, chromosome ...

Inevitable or avoidable?

The prospect of a superbug that could wipe out much of the human race sounds like the stuff of science-fiction novels, Hollywood movies or doomsday prophets. However, such a global pandemic might not be as unlikely as it seems—some would even go so far as to say that it is a certainty, with the only uncertainties being what pathogen will cause it, when it will happen and how well the world will...

Arteriosclerosis: inevitable or self-inflicted?

Over the last 20 years, aortic stiffness has emerged as an important, independent predictor of cardiovascular outcome. Recent data suggest that it may add to existing risk prediction models and improve patient stratification. However, the precise biological pathways and processes underlying aortic stiffening remain unclear. A better understanding of these is an important prerequisite for the ra...